Andreopoulos A G, Plytaria M
Department of Chemical Engineering, National Technical University of Athens, Greece.
J Biomater Appl. 1998 Jan;12(3):258-71. doi: 10.1177/088532829801200306.
Biomedical silicone elastomers have been studied for their potential application as carriers for controlled release of drugs, since these materials display a unique combination of properties, which might be favorable to the above use. A two component silicone gel system was used and various cross-linker ratio was applied, in order to produce networks with varying crosslink density. Swelling experiments in toluene were run in order to evaluate the network characteristics. The silicone elastomer was loaded with salicylic acid and propranolol hydrochloride and their delivery in distilled water was followed. The results showed that release is almost of zero order for high loading of salicylic acid, while delivery seems to be diffusion controlled up to a certain limit. The administered drug concentrations are relatively low if silicone discs are used, due to the hydrophobic nature of this material. On the other hand, when membranes are used with a thickness of 0.1-0.2 mm, then the delivery rate is much higher depending of course on the hydrophilic character of the drug.
生物医学用有机硅弹性体因其作为药物控释载体的潜在应用价值而受到研究，因为这些材料展现出一系列独特的性能组合，这可能有利于上述应用。使用了一种双组分有机硅凝胶体系，并应用了不同的交联剂比例，以制备具有不同交联密度的网络。进行了在甲苯中的溶胀实验，以评估网络特性。将水杨酸和盐酸普萘洛尔负载到有机硅弹性体中，并跟踪它们在蒸馏水中的释放情况。结果表明，对于高负载量的水杨酸，释放几乎为零级，而在达到一定限度之前，释放似乎受扩散控制。如果使用有机硅圆盘，由于这种材料的疏水性，给药的药物浓度相对较低。另一方面，当使用厚度为0.1 - 0.2毫米的膜时，给药速率要高得多，当然这取决于药物的亲水性。
