Watkins L L, Dimsdale J E, Ziegler M G
Department of Psychiatry, University of California at San Diego, La Jolla 92093-0804, USA.
Life Sci. 1995;57(15):1411-6. doi: 10.1016/0024-3205(95)02103-p.
It is well recognized that African Americans have a higher prevalence of cardiovascular disease than White Americans although the underlying mechanisms are not entirely understood. This study was perfumed to evaluate racial differences in the chronotropic and vasodilatory effects of the beta-receptor agonist, isoproterenol. We compared cardiovascular responses to intravenous infusion of isoproterenol in 27 African Americans and 27 White men and women. African Americans showed significantly smaller beta 2-receptor mediated falls in diastolic pressure than Whites. In contrast, isoproterenol produced similar increases in heart rate in both races. The findings suggest that African Americans have decreased beta 2-receptor mediated vasodilatory capacity, and may help explain the higher prevalence of hypertension and cardiovascular disease in African Americans compared to Whites.
众所周知，非裔美国人患心血管疾病的患病率高于美国白人，尽管其潜在机制尚未完全明确。本研究旨在评估β受体激动剂异丙肾上腺素在变时性和血管舒张作用方面的种族差异。我们比较了27名非裔美国人和27名美国白人男女对静脉输注异丙肾上腺素的心血管反应。非裔美国人β2受体介导的舒张压下降幅度明显小于白人。相比之下，异丙肾上腺素在两个种族中引起的心率增加相似。这些发现表明，非裔美国人β2受体介导的血管舒张能力下降，这可能有助于解释非裔美国人与白人相比高血压和心血管疾病患病率较高的原因。
