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Racial differences in drug response: isoproterenol effects on heart rate in healthy males.

作者信息

Rutledge D R, Cardozo L, Steinberg J D

机构信息

Department of Pharmacy Practice, Wayne state University, College of Pharmacy Detroit, Michigan 48202.

出版信息

Pharm Res. 1989 Feb;6(2):182-5. doi: 10.1023/a:1015996929574.

DOI:10.1023/a:1015996929574
PMID:2762218
Abstract

It was the purpose of this study to investigate racial alterations in beta-adrenoceptor response. Two groups of healthy, male volunteers gave their consent. There were eight black Americans (mean age, 26.1 +/- 2.5 years) and eight white/Caucasian Americans (mean age 24.4 +/- 1.8 years). Each subject underwent an isoproterenol sensitivity test. There was a significant (P less than 0.05) decrease in the ratio of Emax to ED50 in the white group (25.3 +/- 6.4) compared with the black group (37.1 +/- 12.4). Over the dose range of 0.1 to 1.0 micrograms there was a significant increase in response at both the 0.25- and the 0.5-microgram dose (P less than 0.05), with the black American group appearing to respond with a greater rate of rise in heart rate following the initial doses.

摘要

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引用本文的文献

1
Racial differences in drug response: isoproterenol effects before and after propranolol.
Pharm Res. 1991 Jun;8(6):754-7. doi: 10.1023/a:1015806202180.
2
Ethnic differences in drug disposition and responsiveness.药物处置和反应性的种族差异。
Clin Pharmacokinet. 1991 May;20(5):350-73. doi: 10.2165/00003088-199120050-00002.

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