急性淋巴细胞白血病中的酸性磷酸酶反应
Acid-phosphatase reaction in acute lymphoblastic leukaemia.
作者信息
Catovsky D, Cherchi M, Greaves M F, Janossy G, Pain C, Kay H E
出版信息
Lancet. 1978 Apr 8;1(8067):749-51. doi: 10.1016/s0140-6736(78)90861-9.
The diagnostic value of the acid-phosphatase reaction was assessed double-blind in 148 cases of acute lymphoblastic leukaemia (A.L.L.) classified by surface-membrane markers and entered into the M.R.C. U.K. A.L.L. trials. 90% of cases of T-A.L.L. showed a positive reaction in the majority of blast cells, while only 2% of common-A.L.L. and 10% of null-A.L.L. were positive. This cytochemical reaction distinguished the more aggressive form of A.L.L. any may aid the choice of therapy.
对148例根据表面膜标记分类并纳入英国医学研究委员会急性淋巴细胞白血病（ALL）试验的急性淋巴细胞白血病患者，采用双盲法评估酸性磷酸酶反应的诊断价值。90%的T-ALL病例在大多数原始细胞中呈阳性反应，而普通ALL仅有2%呈阳性，无标记ALL为10%呈阳性。这种细胞化学反应可区分侵袭性更强的ALL类型，可能有助于治疗方案的选择。
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