Watanabe N, Inoue T, Oriuchi N, Suzuki H, Hirano T, Endo K
Department of Nuclear Medicine, Gunma University School of Medicine, Japan.
Nucl Med Commun. 1995 Jun;16(6):464-7. doi: 10.1097/00006231-199506000-00008.
Measurement of the pulmonary clearance of aerosolized 99Tcm-diethylenetriamine pentaacetate (99Tcm-DTPA) as a marker of pulmonary parenchymal damage was performed in 10 non-smokers with sarcoidosis, none of whom was on medication, and the results compared with 12 normal controls. Posterior images were obtained using a single-headed gamma camera, with the subjects in a supine position, for 30 min after inhalation of aerosolized 99Tcm-DTPA had ceased. The pulmonary clearance of 99Tcm-DTPA was significantly increased in the sarcoidosis patients (57.6 +/- 22.1 min in the right lung, 62.2 +/- 22.7 min in the left lung) compared with the controls (79.3 +/- 10.2 and 78.4 +/- 7.7 min in the right and left lungs, respectively) (P < 0.05). Six of the 10 patients with sarcoidosis showed levels of pulmonary clearance, in both the right and left lungs, below the 95.5% confidence limit (mean +/- 2 S.D.) for the controls. Increased pulmonary clearance of 99Tcm-DTPA was also found in 2 of 4 patients with stage I sarcoidosis. No relationship was found between the pulmonary clearance of 99Tcm-DPTA and inflammatory markers (ACE, lysozyme) in the serum.
对10名结节病非吸烟患者进行了雾化99锝-二乙三胺五醋酸（99Tcm-DTPA）肺清除率的测量，以作为肺实质损伤的标志物，这些患者均未用药，并将结果与12名正常对照者进行比较。在雾化99Tcm-DTPA吸入停止后，让受试者仰卧，使用单头γ相机获取后位图像30分钟。与对照组（右肺79.3±10.2分钟，左肺78.4±7.7分钟）相比，结节病患者的99Tcm-DTPA肺清除率显著增加（右肺57.6±22.1分钟，左肺62.2±22.7分钟）（P<0.05）。10名结节病患者中有6名患者的右肺和左肺肺清除率水平低于对照组的95.5%置信限（均值±2标准差）。在4例I期结节病患者中，也有2例发现99Tcm-DTPA肺清除率增加。未发现99Tcm-DPTA肺清除率与血清中的炎症标志物（血管紧张素转换酶、溶菌酶）之间存在关联。
