Yeh S H, Liu R S, Wu L C, Peng N J, Lu J Y
Department of Nuclear Medicine, Chest Department, Taipei Veterans General Hospital, Taiwan.
Nucl Med Commun. 1995 Mar;16(3):140-4.
The clearance rate of an inhaled aerosol of a lipophilic complex, 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO), was compared with that of a hydrophilic complex, 99Tcm-diethylenetriamine pentaacetate (99Tcm-DTPA), in nine normal subjects and in eight patients with idiopathic pulmonary fibrosis (IPF). Data were acquired as follows. The subjects were placed supine with their back against the scintillation camera and breathed aerosol for 2 min; pulmonary radioactivity was then monitored for 30 min. A time-activity curve (TAC) was generated from the region of interest (ROI) over the periphery of each lung field and a computer program was then used to calculate percentage clearance per minute (k) in each lung. The mean (+/- S.E.M.) rate of clearance of 99Tcm-DTPA (k = 1.31 +/- 0.13% min-1) was not significantly different from that of 99Tcm-HMPAO (k = 1.32 +/- 0.27% min-1, P > 0.025) in the normal subjects. However, 99Tcm-DTPA clearance was 1.91 +/- 0.27% min-1 and 99Tcm-HMPAO clearance 0.78 +/- 0.17% min-1 in eight patients with IPF (P < 0.001, 99Tcm-DTPA vs 99Tcm-HMPAO). By regression analysis using a multiplicative model, both values correlated fairly [r = -0.71, y = exp (0.08-0.85 ln chi); P < 0.005], with a change in clearance rate in the opposite direction in all eight patients. The results of our study demonstrate that the pulmonary clearance of 99Tcm-HMPAO is different from that of 99Tcm-DTPA in IPF.
在9名正常受试者和8名特发性肺纤维化（IPF）患者中，比较了亲脂性复合物99锝-六甲基丙烯胺肟（99Tcm-HMPAO）和亲水性复合物99锝-二乙三胺五乙酸（99Tcm-DTPA）吸入气雾剂的清除率。数据采集如下。受试者仰卧，背部对着闪烁相机，吸入气雾剂2分钟；然后监测肺部放射性30分钟。从每个肺野周边的感兴趣区域（ROI）生成时间-活性曲线（TAC），然后使用计算机程序计算每个肺每分钟的清除率百分比（k）。在正常受试者中，99Tcm-DTPA的平均（±标准误）清除率（k = 1.31±0.13%/分钟）与99Tcm-HMPAO的清除率（k = 1.32±0.27%/分钟，P>0.025）无显著差异。然而，在8名IPF患者中，99Tcm-DTPA清除率为1.91±0.27%/分钟，99Tcm-HMPAO清除率为0.78±0.17%/分钟（P<0.001，99Tcm-DTPA与99Tcm-HMPAO相比）。通过使用乘法模型的回归分析，两个值具有相当的相关性[r = -0.71，y = exp(0.08 - 0.85 ln chi)；P<0.005]，在所有8名患者中清除率变化方向相反。我们的研究结果表明，在IPF中99Tcm-HMPAO的肺部清除率与99Tcm-DTPA不同。
