Adimora A A, Quinlivan E B
Department of medicine, University of North Carolina at Chapel Hill School of Medicine, USA.
Postgrad Med. 1995 Sep;98(3):109-12, 115-6, 120.
Substantial evidence indicates a causal role for human papillomavirus (HPV) infection in the development of cervical dysplasia and cancer. However, since recent advances in HPV detection techniques indicate that genital HPV infection among women is common, it is clear that transient HPV infection is not sufficient for development of cervical malignancy. Oncogenesis may require persistent infection as well as the presence of cofactors that are not yet completely understood. The role of HPV detection and typing in clinical management of HPV-associated lesions is currently being investigated.
大量证据表明，人乳头瘤病毒（HPV）感染在宫颈发育异常和癌症的发生中起因果作用。然而，由于HPV检测技术的最新进展表明，女性生殖器HPV感染很常见，显然短暂的HPV感染不足以导致宫颈恶性肿瘤的发生。肿瘤发生可能需要持续感染以及尚未完全了解的辅助因素的存在。目前正在研究HPV检测和分型在HPV相关病变临床管理中的作用。
