Depoortere H, Françon D, van Luijtelaar E L, Drinkenburg W H, Coenen A M
Synthélabo Recherche (L.E.R.S.), Bagneux, France.
Pharmacol Biochem Behav. 1995 Aug;51(4):571-6. doi: 10.1016/0091-3057(95)00091-a.
Hypnotic drugs are known to possess antiepileptic activity. Therefore, the effects of the benzodiazepine hypnotic midazolam (10 mg/kg) and the novel imidazopyridine hypnotic zolpidem (10 mg/kg) on sleep-wake states and on the number of spike-wave discharges were evaluated in WAG/Rij rats. Rats of this strain are considered to be a model for generalized absence epilepsy. Animals were implanted with chronic monopolar EEG electrodes and, after recovery from surgery, the EEG was recorded for 6 h during the dark period on 3 consecutive days. Sleep recordings were analyzed using Hjorth's parameters and number and duration of spike-wave discharges were visually determined. It was found that both drugs facilitated nonREM sleep at the cost of wakefulness. Both hypnotics also reduced the number and duration of spike-wave discharges. The initial decrease after midazolam, however, was followed by a rebound reflecting a poorer quality of vigilance expressed as an increase in spike-wave discharges. The strong antiabsence activity of zolpidem mimics that of midazolam and is well correlated with their equipotent hypnotic action and anticonvulsant effect in the isoniazid test.
已知催眠药物具有抗癫痫活性。因此，在WAG/Rij大鼠中评估了苯二氮䓬类催眠药咪达唑仑（10毫克/千克）和新型咪唑吡啶类催眠药唑吡坦（10毫克/千克）对睡眠-觉醒状态以及棘波放电次数的影响。该品系大鼠被认为是全身性失神癫痫的模型。给动物植入慢性单极脑电图电极，术后恢复后，在连续3天的黑暗期记录6小时脑电图。使用约尔特参数分析睡眠记录，并通过视觉确定棘波放电的次数和持续时间。结果发现，两种药物均以清醒为代价促进了非快速眼动睡眠。两种催眠药还减少了棘波放电的次数和持续时间。然而，咪达唑仑给药后最初的减少之后出现了反弹，这反映出警觉性质量较差，表现为棘波放电增加。唑吡坦强大的抗失神活性与咪达唑仑相似，并且与其在异烟肼试验中的等效催眠作用和抗惊厥作用密切相关。
