Hata T, Itoh E, Nishikawa H
Department of Pharmacology, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.
Pharmacol Biochem Behav. 1995 Aug;51(4):849-53. doi: 10.1016/0091-3057(95)00057-4.
SART-stressed (repeated cold-stressed) mice exhibited shortened immobility time in forced swimming tests, and a time-dependent increase in the duration of immobility time of stressed mice was less compared to unstressed mice. These changes were blocked by diazepam and alprazolam without influence on the immobility time of unstressed mice. The shortening of immobility time caused by SART stress was inhibited by repeated pretreatment with imipramine and mianserin, but not by a single dose. In contrast, neither single nor repeated administrations of lithium carbonate had effect on the immobility time of SART-stressed mice. The SART stress technique may be a potential model to investigate the relationship between stress and depression with complex symptoms like excessive emotion- and anxiety-related depression.
经SART应激（反复冷应激）的小鼠在强迫游泳试验中静止不动时间缩短，与未应激小鼠相比，应激小鼠静止不动时间的时长随时间的增加较少。地西泮和阿普唑仑可阻断这些变化，且对未应激小鼠的静止不动时间无影响。反复用丙咪嗪和米安色林预处理可抑制SART应激引起的静止不动时间缩短，但单次给药则无此作用。相比之下，碳酸锂单次或反复给药均对SART应激小鼠的静止不动时间无影响。SART应激技术可能是一种潜在模型，用于研究应激与具有过度情绪和焦虑相关抑郁等复杂症状的抑郁症之间的关系。
