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Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors.

作者信息

Schmeller T, Sporer F, Sauerwein M, Wink M

机构信息

Institut für Pharmazeutische Biologie, Universität Heidelberg.

出版信息

Pharmazie. 1995 Jul;50(7):493-5.

PMID:7675895
Abstract

Fourteen tropane and related alkaloids were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. The biogenetic intermediates littorine, 6 beta-hydroxyhyoscyamine, 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine. The quarternary derivatives N-methylatropine and N-methylscopolamine show the highest binding with IC50 values of less than 100 pM and 300 pM, respectively. The tropane alkaloids (including cocaine) also bind to the nicotinic acetylcholine receptor, albeit with much lower affinities.

摘要

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