Schmeller T, Sauerwein M, Sporer F, Wink M, Müller W E
Universität Heidelberg, Institut für Pharmazeutische Biologie, Germany.
J Nat Prod. 1994 Sep;57(9):1316-9. doi: 10.1021/np50111a026.
Fourteen quinolizidine alkaloids, isolated from Lupinus albus, L. mutabilis, and Anagyris foetida, were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. Of the compounds tested, the alpha-pyridones, N-methylcytisine and cytisine, showed the highest affinities at the nicotinic receptor, while several quinolizidine alkaloid types were especially active at the muscarinic receptor.
对从白羽扇豆、多变羽扇豆和臭豆中分离出的14种喹诺里西啶生物碱进行了分析，以研究它们对烟碱型和/或毒蕈碱型乙酰胆碱受体的亲和力。在所测试的化合物中，α-吡啶酮、N-甲基金雀花碱和金雀花碱对烟碱型受体表现出最高的亲和力，而几种喹诺里西啶生物碱类型对毒蕈碱型受体特别有活性。
