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[癌前病变和子宫内膜癌患者外周血淋巴细胞的染色体结构畸变]

[Structural chromosome aberrations in the peripheral blood lymphocytes in patients with precancer and endometrial cancer].

作者信息

Polishchuk L Z, Nesina I P

出版信息

Tsitol Genet. 1995 May-Jun;29(3):17-24.

PMID:7676506
Abstract

The level of chromosomal aberrations in cultured blood lymphocytes from patients with hyperplasia, atypical hyperplasia of endometrium and endometrial cancer was studied. Chromosomal aberration frequency significantly increased up to 5.000 +/- 00.47% in patients with atypical and endometrial hyperplasia and to 5.21 +/- 00.53% in patients with endometrial cancer in comparison to 0.67 +/- 0.21% in the control. All indices were more pronounced in endometrial cancer patients with pathology in pedigree.

摘要

研究了子宫内膜增生、非典型增生和子宫内膜癌患者培养的血液淋巴细胞中的染色体畸变水平。与对照组的0.67±0.21%相比,非典型增生和子宫内膜增生患者的染色体畸变频率显著增加,高达5.000±00.47%,子宫内膜癌患者的染色体畸变频率增加到5.21±00.53%。在有家族病史的子宫内膜癌患者中,所有指标更为明显。

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