Tolino A, Di Serio C, Caracciolo G B, Tartaglia E, Riccio S
II Facoltà di Medicina e Chirurgia, Università degli Studi Federico II, Napoli.
Minerva Ginecol. 1991 Nov;43(11):495-7.
The Authors examine serum levels of HPRL in basal conditions and after TRH and sulpiride test in 15 patients with endometrial lesions (hyperplasia) and in 15 patients with endometrial adenocarcinoma included in a age range between 44 and 62 years, in which 7 patients present obesity, 10 patients present hypertension and 2 patients are hyperglycemic. The same examination is carried out in a control group of 30 healthy patients. Then the 15 patients with adenocarcinoma and 3 patients with adenomatosa hyperplasia are subjected to surgery and they estimate HPRL levels in endometrium. The results prove that there is no correlation between HPRL plasma levels and endometrium lesions and between endometrium HPRL. The Authors conclude that HPRL does not play a significant role in the pathogenesis of endometrial lesions; use of HPRL plasma levels as a marker of endometrial lesions is not possible.
作者检测了15例子宫内膜病变(增生)患者和15例子宫内膜腺癌患者在基础状态下以及促甲状腺激素释放激素(TRH)和舒必利试验后的血清高泌乳素(HPRL)水平,这些患者年龄在44至62岁之间,其中7例肥胖,10例高血压,2例高血糖。对30名健康患者组成的对照组进行了同样的检测。然后,对15例腺癌患者和3例腺瘤样增生患者进行手术,并测定子宫内膜中的HPRL水平。结果证明,血浆HPRL水平与子宫内膜病变以及子宫内膜HPRL之间均无相关性。作者得出结论,HPRL在子宫内膜病变的发病机制中不起重要作用;不可能将血浆HPRL水平用作子宫内膜病变的标志物。