Hsieh Y D, Devlin H, McCord F
Department of Dental Medicine and Surgery, University Dental Hospital of Manchester, U.K.
Arch Oral Biol. 1995 Jun;40(6):529-31. doi: 10.1016/0003-9969(94)00197-j.
Under general anaesthesia, 35-day-old female rats were ovariectomized and the right maxillary molar teeth removed. Dynamic measures of alveolar bone formation were determined at 10 days after surgery, using the fluorochrome labelling technique, and compared with control animals. Ovariectomy significantly increased buccal resorption and palatal bone formation. In a second experiment, ovariectomized rats had the right maxillary molar teeth extracted and were killed at either 5 or 14 days after surgery. The mean mineralizing surface of the alveolar bone (percentage of surfaces occupied by a double fluorescent label) was significantly lower in rats killed at either 5 or 10 days than at 14 days after ovariectomy and tooth extraction. The mean appositional rate was significantly greater at 5 days after ovariectomy and tooth extraction than at 10 or 14 days. Oestrogen deficiency can therefore affect alveolar bone turnover following tooth extraction.
在全身麻醉下，对35日龄的雌性大鼠进行卵巢切除，并拔除右上颌磨牙。术后10天，采用荧光染料标记技术测定牙槽骨形成的动态指标，并与对照动物进行比较。卵巢切除显著增加了颊侧吸收和腭侧骨形成。在第二个实验中，对卵巢切除的大鼠拔除右上颌磨牙，并在术后5天或14天处死。卵巢切除和拔牙后5天或10天处死的大鼠，牙槽骨的平均矿化表面（被双荧光标记占据的表面百分比）显著低于术后14天处死的大鼠。卵巢切除和拔牙后5天的平均沉积率显著高于10天或14天。因此，雌激素缺乏会影响拔牙后的牙槽骨转换。
