Hsieh Y D, Devlin H, Roberts C
Department of Restorative Dentistry, University Dental Hospital of Manchester, U.K.
Arch Oral Biol. 1994 May;39(5):425-8. doi: 10.1016/0003-9969(94)90173-2.
Following tooth extraction, fluorochrome bone labels were injected intraperitoneally at intervals to identify mineralizing bone surfaces. At 5, 10 and 14 days post-extraction, the rats were killed. The mineral apposition rate, mineralizing surface and mineral formation rate were determined at various locations around the healing tooth socket. Linear trends in mineral apposition rate (p < 0.000001), mineralizing surface (p < 0.000001) and mineral formation rate (p = 0.00008) were seen around the socket, decreasing from gingivopalatal to gingivobuccal regions. These differences may be due to variations in vascularity as the gingivopalatal region is adjacent to the greater palatine artery. The mineral formation rate and mineralizing surface were significantly higher in the rats killed at 14 days after tooth extraction than at the other two post-extraction time points. This may be related to an earlier peak rate of bone resorption.
拔牙后，每隔一段时间经腹腔注射荧光色素骨标记物以识别矿化骨表面。拔牙后5天、10天和14天，处死大鼠。测定愈合牙槽窝周围不同位置的矿物质沉积率、矿化表面和矿物质形成率。牙槽窝周围矿物质沉积率（p < 0.000001）、矿化表面（p < 0.000001）和矿物质形成率（p = 0.00008）呈线性趋势，从龈腭侧到龈颊侧逐渐降低。这些差异可能是由于龈腭侧区域靠近腭大动脉，血管分布不同所致。拔牙后14天处死的大鼠的矿物质形成率和矿化表面显著高于拔牙后其他两个时间点。这可能与较早出现的骨吸收峰值速率有关。
