Li X, Nishimura I
Harvard School of Dental Medicine, Boston, Mass.
J Prosthet Dent. 1994 Sep;72(3):324-30. doi: 10.1016/0022-3913(94)90348-4.
This study investigated the effect of estrogen deficiency on residual ridge remodeling after tooth extraction. Ovariectomy was performed on female Sprague-Dawley rats, and the plasma levels of estrogen and progesterone were monitored. The maxillary molars of the ovariectomized and control rats were extracted and the remodeling residual ridge tissues were harvested at 2, 4, and 8 weeks postextraction. The specimens were examined at the mesiodistal center point of the residual ridge by use of light and scanning electron microscopy. The surface of the residual ridge of the control animals showed a number of osteoclastic lacunae indicating bone resorption activity. In the ovariectomized animals, the surface of the residual alveolar bone was partially covered by a distinct calcified tissue. This tissue contained large cells and a mesh-like structure of thin calcified extracellular matrix consistent with the tissue characteristics of chondroid bone. The chondroid bone-like calcified tissue was found only in the ovariectomized animals throughout the experiment period. This study's data suggest that a systemic condition such as estrogen deficiency due to ovariectomy may alter the phenotypic expression of cells associated with the residual ridge and result in less osteoclastic activity and a different type of calcified tissue.
本研究调查了雌激素缺乏对拔牙后剩余牙槽嵴改建的影响。对雌性Sprague-Dawley大鼠进行卵巢切除术，并监测血浆中雌激素和孕酮水平。将去卵巢大鼠和对照大鼠的上颌磨牙拔除，并在拔牙后2周、4周和8周采集剩余牙槽嵴组织进行改建研究。通过光学显微镜和扫描电子显微镜在剩余牙槽嵴的近远中中心点对标本进行检查。对照动物剩余牙槽嵴表面可见多个破骨细胞陷窝，提示有骨吸收活动。在去卵巢动物中，剩余牙槽骨表面部分被一种独特的钙化组织覆盖。该组织含有大细胞和由薄的钙化细胞外基质构成的网状结构，与类软骨骨的组织特征一致。在整个实验期间，仅在去卵巢动物中发现类软骨骨样钙化组织。本研究数据表明，卵巢切除导致的雌激素缺乏等全身状况可能会改变与剩余牙槽嵴相关细胞的表型表达，导致破骨细胞活性降低和出现不同类型的钙化组织。
