Singhal A, Davies P, Sahota A, Thomas P W, Serjeant G R
Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.
Am J Clin Nutr. 1993 Jan;57(1):32-4. doi: 10.1093/ajcn/57.1.32.
The resting metabolic rate in 20 patients with homozygous sickle cell (SS) disease was 19% higher than in 20 age- and sex-matched control subjects with a normal hemoglobin genotype (AA). The difference was not accounted for by differences in lean body mass. It is postulated that this increased energy expenditure reflects the energy expenditure of erythropoietic hyperplasia and leads to a marginal nutritional state that may contribute to the abnormal growth in SS disease.
20例纯合子镰状细胞（SS）病患者的静息代谢率比20例年龄和性别匹配、血红蛋白基因型正常（AA）的对照受试者高19%。这种差异不能用瘦体重的差异来解释。据推测，这种能量消耗增加反映了红细胞生成增生的能量消耗，并导致边缘性营养状态，这可能是导致SS病生长异常的原因之一。
