Idjradinata P, Pollitt E
Department of Child Health, Medical Faculty, Padjadjaran University, Bandung, Indonesia.
Lancet. 1993 Jan 2;341(8836):1-4. doi: 10.1016/0140-6736(93)92477-b.
Iron-deficient anaemic infants perform worse in tests of mental and motor development than do iron-sufficient infants of a comparable age. A randomised, double-blind trial was done to monitor the effects of iron supplementation on performance in the Bayley scales of mental and motor development among 12-18-month-old infants in Indonesia. Iron-deficient anaemic infants (n = 50) were assigned randomly to receive dietary ferrous sulphate or placebo for 4 month. Similar treatment randomisation was done among nonanaemic iron-deficient (n = 29) and iron-sufficient (n = 47) infants. Before intervention, the mean mental and motor scores of the iron-deficient anaemic infants were significantly (p < 0.01) lower than those of the nonanaemic iron-deficient and iron-sufficient classes. After intervention, developmental delays were reversed among iron-deficient anaemic infants who had received iron but they remained the same among placebo-treated iron-deficient anaemic infants. Neither ferrous sulphate nor placebo had significant effects on the scores of the other two iron-status classes. The poor performance of 12-18-month-old iron-deficient anaemic infants in the Bayley scales of mental and motor development can be improved to the level of performance of iron-sufficient infants by treatment with ferrous sulphate.
缺铁性贫血婴儿在智力和运动发育测试中的表现比同龄的铁充足婴儿差。在印度尼西亚，开展了一项随机双盲试验，以监测补充铁剂对12至18个月大婴儿贝利智力和运动发育量表表现的影响。缺铁性贫血婴儿（n = 50）被随机分配接受膳食硫酸亚铁或安慰剂，为期4个月。在非贫血性缺铁婴儿（n = 29）和铁充足婴儿（n = 47）中进行了类似的治疗随机分组。干预前，缺铁性贫血婴儿的平均智力和运动得分显著低于（p < 0.01）非贫血性缺铁组和铁充足组婴儿。干预后，接受铁剂治疗的缺铁性贫血婴儿的发育迟缓得到了逆转，但接受安慰剂治疗的缺铁性贫血婴儿的发育迟缓情况仍未改变。硫酸亚铁和安慰剂对其他两个铁状态组的得分均无显著影响。通过硫酸亚铁治疗，12至18个月大的缺铁性贫血婴儿在贝利智力和运动发育量表中的不佳表现可改善至铁充足婴儿的水平。
