Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
Nutrients. 2021 Oct 9;13(10):3533. doi: 10.3390/nu13103533.
The rise in the prevalence of obesity and other related metabolic diseases has been paralleled by an increase in the frequency of neurodevelopmental problems, which has raised the likelihood of a link between these two phenomena. In this scenario, maternal microbiota is a possible linking mechanistic pathway. According to the "Developmental Origins of Health and Disease" paradigm, environmental exposures (in utero and early life) can permanently alter the body's structure, physiology, and metabolism, increasing illness risk and/or speeding up disease progression in offspring, adults, and even generations. Nutritional exposure during early developmental stages may induce susceptibility to the later development of human diseases via interactions in the microbiome, including alterations in brain function and behavior of offspring, as explained by the gut-brain axis theory. This review provides an overview of the implications of maternal nutrition on neurodevelopmental disorders and the establishment and maturation of gut microbiota in the offspring.
肥胖症和其他相关代谢性疾病的患病率不断上升，与此同时，神经发育问题的发生频率也有所增加，这使得这两种现象之间可能存在关联。在这种情况下，母体微生物群可能是一种潜在的关联机制途径。根据“健康与疾病的发育起源”范式，环境暴露（子宫内和生命早期）可以永久性地改变身体的结构、生理和代谢，增加后代、成年人甚至几代人的疾病风险和/或加速疾病进展。早期发育阶段的营养暴露可能会通过微生物组的相互作用导致人类疾病的易感性增加，包括改变后代的大脑功能和行为，这可以用肠道-大脑轴理论来解释。本综述概述了母体营养对神经发育障碍以及后代肠道微生物群的建立和成熟的影响。
