Charoenlarp P, Dhanamitta S, Kaewvichit R, Silprasert A, Suwanaradd C, Na-Nakorn S, Prawatmuang P, Vatanavicharn S, Nutcharas U, Pootrakul P
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Am J Clin Nutr. 1988 Feb;47(2):280-97. doi: 10.1093/ajcn/47.2.280.
Studies on the treatment and prevention of iron deficiency anemia, in pregnant and nonpregnant women and in men, were conducted in Thailand and Burma. The effects of the dose of Fe, duration of Fe administration, additional supplementation with folate, mode of supplement delivery (either supervised or unsupervised), and the presence of Hb(AE) were studied. The frequency and severity of side effects were also recorded. Fe administration resulted in an increase in hemoglobin concentration in all anemic individuals but approximately 20% failed to reach normality. The length of administration and the dose influenced the results. Frequency and severity of side effects increased with the dose of Fe administered. Folate supplementation did not affect the results. It appears possible to integrate a program of prevention and treatment of Fe deficiency anemia in a primary health-care system but the constraints and limitations of achievable results should be recognized.
在泰国和缅甸，针对孕妇、非孕妇及男性缺铁性贫血的治疗与预防展开了研究。研究了铁剂量、铁剂服用时长、额外补充叶酸、补充方式（监督或非监督）以及血红蛋白（AE）的存在情况的影响。还记录了副作用的发生频率和严重程度。铁剂给药使所有贫血个体的血红蛋白浓度有所上升，但约20%未恢复至正常水平。给药时长和剂量影响了结果。副作用的发生频率和严重程度随铁剂给药剂量增加而上升。补充叶酸并未影响结果。在初级卫生保健系统中整合缺铁性贫血预防和治疗方案似乎是可行的，但应认识到可实现结果的限制和局限性。
