Khan P K, Sinha S P
Department of Zoology, Bhagalpur University, India.
Mutat Res. 1993 Jan;298(3):157-61. doi: 10.1016/0165-1218(93)90036-d.
Vitamin C, when administered concurrently with a pesticide (endosulfan, phosphamidon or mancozeb), could significantly decrease the frequency of pesticide-induced clastogenic and mitosis-disruptive changes in the bone marrow cells of young Swiss albino mice. Of the three doses (10, 20 or 40 mg/kg b.wt./day) of the vitamin, the one which is double the human therapeutic dose (20 mg/kg b.wt./day) was most effective as an antimutagen to be followed by 40 mg and 10 mg. None of these doses of vitamin C showed any genotoxicity of their own for the parameters studied here.
维生素C与一种农药（硫丹、磷胺或代森锰锌）同时给药时，可显著降低农药诱导的年轻瑞士白化小鼠骨髓细胞的致断裂和有丝分裂破坏变化的频率。在维生素的三种剂量（10、20或40毫克/千克体重/天）中，是人类治疗剂量（20毫克/千克体重/天）两倍的剂量作为抗诱变剂最有效，其次是40毫克和10毫克。这里研究的参数表明，这些维生素C剂量自身均未显示出任何遗传毒性。
