Bose S, Sinha S P
Department of Zoology, Bhagalpur University, India.
Food Chem Toxicol. 1994 Jun;32(6):533-7. doi: 10.1016/0278-6915(94)90110-4.
Ochratoxin A (OA), when administered orally daily for 45 days to albino Swiss mice, Mus musculus, at a level equivalent to the human dietary concentration of 1 microgram/kg body weight/day, increased the production of abnormalities in both mitotic and meiotic chromosomes as well as in the gross morphology of the sperm head. The sperm count per unit volume of caput epididymal suspension also decreased. Vitamin C at a concentration equivalent to the human therapeutic dose (10 mg/kg body weight/day), when administered orally concurrently with OA, significantly minimized the incidence of these abnormalities. The protective effect of vitamin C was most marked in mitotic chromosomes followed by that in meiotic chromosomes and sperm head morphology; the improvement in sperm count was least marked. The possible mechanism of this effect is discussed.
给瑞士白化小鼠（小家鼠）每日经口投喂赭曲霉毒素A（OA），剂量相当于人类饮食中1微克/千克体重/天的浓度，持续45天，结果显示，有丝分裂和减数分裂染色体以及精子头部的总体形态异常增多。每单位体积附睾头悬液中的精子计数也减少。当与OA同时经口给予浓度相当于人类治疗剂量（10毫克/千克体重/天）的维生素C时，这些异常的发生率显著降低。维生素C的保护作用在有丝分裂染色体中最为明显，其次是减数分裂染色体和精子头部形态；精子计数的改善最不明显。本文讨论了这种作用的可能机制。
