Aikawa K, Miwa M
National Institute of Animal Industry, Ibaraki, Japan.
Mutat Res. 1993 Feb;301(2):93-7. doi: 10.1016/0165-7992(93)90030-y.
The effect of temperature on the antimutagenic activity of acrolein was investigated using UV-irradiated E. coli B. When incubated at lower temperatures (30 degrees C or 37 degrees C), acrolein greatly reduced the mutation frequency in WP2 (wild-type strain), but no such effect was observed with WP2s and ZA159 (excision repair-deficient strains). The antimutagenic activity of acrolein increased when cells were incubated at higher temperatures (40 degrees C or 42 degrees C). Particularly in excision repair-deficient strains, the antimutagenic activity was observed only at higher temperatures. In heat shock response-deficient background, however, the antimutagenic activity was observed at 30 degrees C even in the excision repair-deficient strains.
使用紫外线照射的大肠杆菌B研究了温度对丙烯醛抗诱变活性的影响。当在较低温度（30℃或37℃）下培养时，丙烯醛大大降低了WP2（野生型菌株）中的突变频率，但在WP2s和ZA159（切除修复缺陷型菌株）中未观察到这种效果。当细胞在较高温度（40℃或42℃）下培养时，丙烯醛的抗诱变活性增加。特别是在切除修复缺陷型菌株中，仅在较高温度下观察到抗诱变活性。然而，在热休克反应缺陷型背景下，即使在切除修复缺陷型菌株中，在30℃也观察到了抗诱变活性。
