Murono K, Fujita K, Yoshikawa M, Saijo M, Inyaku F, Kakehashi H, Tsukamoto T
Department of Pediatrics, Asahikawa Medical College, Japan.
J Pediatr. 1993 Jan;122(1):120-5. doi: 10.1016/s0022-3476(05)83504-8.
To determine whether Escherichia coli strains that colonize the intestinal tract of newborn infants in hospitals are of maternal origin or come from the environment, plasmid profiles of E. coli strains isolated from the stools of infants were compared with those from the stools of their mothers. Twenty-nine mother-infant pairs were studied in three different hospitals. In only 4 of 29 pairs, plasmid profiles of E. coli or other Enterobacteriaceae were shared by infant and mother; vertical transmission seemed to be uncommon, unlike findings in previous reports. In one hospital, 8 of 10 infant fecal E. coli strains shared a single plasmid profile, strongly suggesting nosocomial acquisition. In another, 7 of 9 neonate strains also shared a unique profile, and additionally carried K1 capsular antigen, a known virulence factor. Two other infants from the latter nursery acquired a urinary tract infection with E. coli K1 carrying the same plasmid profile. This study indicates that nosocomial acquisition of hospital strains of E. coli by neonates may be common in some hospitals and that the clinical implications are potentially serious.
为确定医院中定植于新生儿肠道的大肠杆菌菌株是源自母体还是来自环境，将从婴儿粪便中分离出的大肠杆菌菌株的质粒图谱与其母亲粪便中的质粒图谱进行了比较。在三家不同的医院对29对母婴进行了研究。在29对母婴中，只有4对母婴的大肠杆菌或其他肠杆菌科细菌的质粒图谱相同；与之前的报道结果不同，垂直传播似乎并不常见。在一家医院，10株婴儿粪便大肠杆菌菌株中有8株具有单一的质粒图谱，强烈提示为医院内获得。在另一家医院，9株新生儿菌株中有7株也具有独特的图谱，并且还携带K1荚膜抗原，这是一种已知的毒力因子。后一家托儿所的另外两名婴儿感染了携带相同质粒图谱的大肠杆菌K1引起的尿路感染。这项研究表明，在一些医院中，新生儿医院内获得医院来源的大肠杆菌菌株可能很常见，并且其临床意义可能很严重。
