Ikäheimo R, Siitonen A, Kärkkäinen U, Mäkelä P H
Department of Medicine, Kuopio University Hospital, Finland.
Clin Infect Dis. 1993 Jun;16(6):785-91. doi: 10.1093/clind/16.6.785.
We examined 148 strains of Escherichia coli isolated from the urine from patients with nosocomial urinary tract infection (UTI). The prevalence of P fimbriation was only 11.5%. Of the strains, 17.6% expressed non-P M(R) adhesins (defined as strains expressing mannose-resistant but not P-specific hemagglutination); 33.1% produced hemolysin, and 15.2% expressed type 1C fimbriae. O6 was the most common group of O antigens (12.2%), closely followed by O75 (9.5%); both of these groups are relatively uncommon (4.5% and 1%, respectively) in fecal strains isolated from healthy adults. Of the strains with O6 and O75 antigens, 78.8% and 79% produced hemolysin, but of all other strains causing UTI, only 21% produced hemolysin. Of the strains with O6 antigens, 61% expressed non-P M(R) adhesins, but only 12% of all other strains causing UTI expressed non-P M(R) adhesins. There were no significant differences in the prevalence of virulence properties between strains isolated from patients with or without an underlying medical illness or between strains causing different clinical categories of UTI. We conclude that the prevalence of bacterial virulence factors is low among patients with nosocomial UTI.
我们检测了从医院获得性尿路感染（UTI）患者尿液中分离出的148株大肠杆菌。P菌毛的发生率仅为11.5%。在这些菌株中，17.6%表达非P M（R）黏附素（定义为表达甘露糖抗性但非P特异性血凝的菌株）；33.1%产生溶血素，15.2%表达1C型菌毛。O6是最常见的O抗原组（12.2%），紧随其后的是O75（9.5%）；这两组在从健康成年人分离的粪便菌株中相对不常见（分别为4.5%和1%）。在具有O6和O75抗原的菌株中，78.8%和79%产生溶血素，但在所有其他引起UTI的菌株中，只有21%产生溶血素。在具有O6抗原的菌株中，61%表达非P M（R）黏附素，但在所有其他引起UTI的菌株中，只有12%表达非P M（R）黏附素。从有或没有基础疾病的患者中分离出的菌株之间，或在引起不同临床类型UTI的菌株之间，毒力特性的发生率没有显著差异。我们得出结论，医院获得性UTI患者中细菌毒力因子的发生率较低。
