对啮齿动物致癌性生物测定结果进行分层，以反映相对的人类危害。
Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard.
作者信息
Tennant R W
机构信息
Experimental Carcinogenesis and Mutagenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Mutat Res. 1993 Mar;286(1):111-8. doi: 10.1016/0027-5107(93)90006-2.
PMID:7678907
Abstract
Trans-species, multiple site (particularly common site between species), mutagenic rodent carcinogens are less affected by the influences of polymorphic genes than are chemicals inducing more limited carcinogenic effects. Trans-species carcinogens, therefore, should represent a first priority for attention for human health risk.
摘要
跨物种、多部位（尤其是物种间的常见部位）的致突变性啮齿动物致癌物受多态性基因影响的程度低于诱导更有限致癌效应的化学物质。因此，跨物种致癌物应成为人类健康风险关注的首要重点。
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