Corchia C, Sanna M C, Serra C, Balata A, Orzalesi M
Department of Child Health and Neonatology, University of Sassari Medical School, Italy.
Paediatr Perinat Epidemiol. 1993 Jan;7(1):55-66. doi: 10.1111/j.1365-3016.1993.tb00601.x.
'Idiopathic' hyperbilirubinaemia in the first 4 days of life was studied in 431 unselected healthy full-term (gestational age > or = 37 weeks) singleton Sardinian infants with birthweight > or = 2500 g. All infants were free from malformations or any disease requiring treatment other than jaundice, they were ABO and Rh compatible with their mothers and were not G6PD deficient. The serum bilirubin level was > 11.9 mg/dl (204 mumol/l) and > 14.9 mg/dl (256 mumol/l) in 37.1% and 15.3% of the study subjects. The vast majority of the infants (94%) were breast fed; no difference in the incidence of jaundice was found between breast-fed and bottle-fed infants. A logistic regression analysis indicated that high alpha-fetoprotein concentrations in cord blood, history of neonatal jaundice in previous full-term siblings, delayed first meconium passage and weight loss were associated with jaundice, defined as a serum bilirubin level > 11.9 mg/dl. These results suggest that the high rate of neonatal hyperbilirubinaemia in Sardinia is mostly related to constitutional and possibly hereditary factors.
对431名未经过挑选的健康足月（胎龄≥37周）、出生体重≥2500克的撒丁岛单胎婴儿出生后前4天的“特发性”高胆红素血症进行了研究。所有婴儿均无畸形或除黄疸外需要治疗的任何疾病，他们与母亲的ABO和Rh血型相容，且无葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症。研究对象中37.1%和15.3%的血清胆红素水平分别>11.9毫克/分升（204微摩尔/升）和>14.9毫克/分升（256微摩尔/升）。绝大多数婴儿（94%）为母乳喂养；母乳喂养和人工喂养婴儿的黄疸发生率无差异。逻辑回归分析表明，脐血中甲胎蛋白浓度高、之前足月同胞有新生儿黄疸病史、首次胎粪排出延迟和体重减轻与黄疸相关，黄疸定义为血清胆红素水平>11.9毫克/分升。这些结果表明，撒丁岛新生儿高胆红素血症的高发生率主要与体质因素以及可能的遗传因素有关。
