Clarkson J E, Cowan J O, Herbison G P
Aust Paediatr J. 1984 Nov;20(4):303-8. doi: 10.1111/j.1440-1754.1984.tb00099.x.
A geographically based population of 498 full term, appropriate for gestational age, healthy, singleton neonates was used to study the effect of obstetric and nursery practices on the occurrence of neonatal jaundice. At 3-4 days 56% of babies became visibly jaundiced (plasma bilirubin (PB) greater than 100 mumol/l) and 10% were hyperbilirubinaemic (PB greater than 200 mumol/l). Less mature babies, those slow to pass meconium and those who had lost weight at 4 and 7 days were more likely to be jaundiced. Obstetric practices, drugs given during labour, mother's or baby's blood group, natural illumination, plethora, extravasated blood or mode of feeding were found to have no effect. No benefit from giving supplementary milk or dextrose to breast fed babies was discovered. At 6-7 days at least 9% of babies, all but one of whom were breast fed, were visibly jaundiced. The frequency of prolonged jaundice (breast milk jaundice) was 3.8% of breast fed babies at 3 weeks and zero by 7 weeks. The proportion of babies receiving phototherapy was 2.2%.
以一个基于地理位置的498名足月儿群体为研究对象，这些婴儿均为适于胎龄、健康的单胎新生儿，旨在研究产科和新生儿护理措施对新生儿黄疸发生情况的影响。在出生3 - 4天时，56%的婴儿出现明显黄疸（血浆胆红素（PB）大于100 μmol/L），10%为高胆红素血症（PB大于200 μmol/L）。成熟度较低的婴儿、胎粪排出缓慢的婴儿以及在出生4天和7天时体重减轻的婴儿更易出现黄疸。研究发现，产科措施、分娩期间使用的药物、母亲或婴儿的血型、自然光照、多血质、血液外渗或喂养方式均无影响。未发现给母乳喂养的婴儿补充牛奶或葡萄糖有任何益处。在出生6 - 7天时，至少9%的婴儿出现明显黄疸，其中除1名婴儿外均为母乳喂养。持续性黄疸（母乳性黄疸）在3周时占母乳喂养婴儿的3.8%，到7周时为零。接受光疗的婴儿比例为2.2%。
