慕尼黑沙门氏菌鞭毛抗原d的T细胞表位定位
Mapping of T-cell epitopes of flagellar antigen d of Salmonella muenchen.
作者信息
Joys T M, Street N E
机构信息
Department of Microbiology, Texas Tech University Health Science Center, Lubbock 79430.
出版信息
Infect Immun. 1993 Mar;61(3):1146-8. doi: 10.1128/iai.61.3.1146-1148.1993.
Abstract
Regions of the antigen d flagellin of Salmonella muenchen capable of causing the proliferation of repolymerized d flagellin-primed T cells were delineated by using dodecameric peptides. Three areas causing substantial DNA replication were identified, together with five areas eliciting less response. On the basis of known salmonella flagellin structure, the major areas were located in highly conserved regions of the molecule.
摘要
通过使用十二聚体肽来划定慕尼黑沙门氏菌的抗原d鞭毛蛋白中能够引起再聚合的d鞭毛蛋白致敏T细胞增殖的区域。确定了三个引起大量DNA复制的区域，以及五个引起较弱反应的区域。根据已知的沙门氏菌鞭毛蛋白结构，主要区域位于该分子的高度保守区域。
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本文引用的文献
1
Covalent structure of three phase-1 flagellar filament proteins of Salmonella.沙门氏菌三种1期鞭毛丝蛋白的共价结构
J Mol Biol. 1985 Dec 20;186(4):791-803. doi: 10.1016/0022-2836(85)90397-3.
2
The flagellar filament protein.鞭毛丝蛋白。
Can J Microbiol. 1988 Apr;34(4):452-8. doi: 10.1139/m88-078.
3
Immune response to cholera toxin epitope inserted in Salmonella flagellin.对插入沙门氏菌鞭毛蛋白中的霍乱毒素表位的免疫反应。
Science. 1989 Apr 7;244(4900):70-2. doi: 10.1126/science.2468182.
4
Amino acids responsible for flagellar shape are distributed in terminal regions of flagellin.负责鞭毛形状的氨基酸分布在鞭毛蛋白的末端区域。
J Mol Biol. 1991 Jun 5;219(3):471-80. doi: 10.1016/0022-2836(91)90187-b.
5
Role of single amino acids in the recognition of a T cell epitope.单个氨基酸在T细胞表位识别中的作用。
J Immunol. 1991 Oct 15;147(8):2507-13.
6
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J Exp Med. 1991 Mar 1;173(3):609-17. doi: 10.1084/jem.173.3.609.
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