沙门氏菌g...鞭毛抗原复合物的分子分析。
Molecular analyses of the Salmonella g. . . flagellar antigen complex.
作者信息
Masten B J, Joys T M
机构信息
Department of Microbiology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
出版信息
J Bacteriol. 1993 Sep;175(17):5359-65. doi: 10.1128/jb.175.17.5359-5365.1993.
Abstract
Salmonella flagellar filaments are polymers of a highly antigenic protein, termed flagellin. Eight main subfactors have been identified in the Salmonella phase-1 g. . . series flagellar antigen. To determine the molecular basis for expression of the epitopes by which the g. . . family subfactors are distinguished, 10 members of this series were selected and their fliC (the structural gene for phase-1 flagellin) genes were sequenced. Comparative analyses of the inferred primary structures of these flagellins did not allow the identification of linear epitopes responsible for the antigen subfactors. This suggests that conformational aspects are involved in determining the antigenic specificity in these cases. A phylogenetic analysis of the flagellin sequences showed that members of the g. . . series do not form a single coherent unit.
摘要
沙门氏菌鞭毛丝是一种高度抗原性蛋白质（称为鞭毛蛋白）的聚合物。在沙门氏菌1相g...系列鞭毛抗原中已鉴定出八个主要亚因子。为了确定区分g...家族亚因子的表位表达的分子基础，选择了该系列的10个成员，并对它们的fliC（1相鞭毛蛋白的结构基因）基因进行了测序。对这些鞭毛蛋白推断的一级结构的比较分析未能鉴定出负责抗原亚因子的线性表位。这表明在这些情况下，构象方面参与了抗原特异性的决定。对鞭毛蛋白序列的系统发育分析表明，g...系列的成员并不形成一个单一的连贯单元。
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