Ding Z Q, Li Y W, Wesselingh S L, Blessing W W
Department of Medicine, Flinders University, Bedford Park, South Australia.
J Auton Nerv Syst. 1993 Jan;42(1):23-31. doi: 10.1016/0165-1838(93)90338-u.
We mapped the distribution of virus-labelled neurons in the brain after injection of Herpes simplex virus type 1 (HSV1) into the rabbit renal nerve. Seven days after injection, labelled neurons were observed in four brain regions, the rostral ventrolateral medulla (47 +/- 3% of neurons), the A5 area of the lower pons (38 +/- 4%), the caudal raphe nuclei and the parapyramidal area of the medulla (13 +/- 2%), and the paraventricular nucleus of the hypothalamus (1 +/- 1%). In the rostral ventrolateral medulla approximately one half of the HSV1-labelled neurons also contained tyrosine hydroxylase, characterizing them as C1 neurons. In the A5 area virtually all HSV1-labelled neurons also contained tyrosine hydroxylase. In the raphe nuclei and the parapyramidal area 47% of HSV1-positive neurons contained serotonin. The distribution of labelled neurons was similar to that observed after injection of HSV1 into the adrenal gland.
我们将1型单纯疱疹病毒（HSV1）注入兔肾神经后，绘制了大脑中病毒标记神经元的分布图。注射7天后，在四个脑区观察到标记神经元，分别是延髓头端腹外侧区（占神经元的47±3%）、脑桥下部的A5区（38±4%）、延髓尾侧中缝核和锥体旁区（13±2%）以及下丘脑室旁核（1±1%）。在延髓头端腹外侧区，大约一半的HSV1标记神经元也含有酪氨酸羟化酶，表明它们为C1神经元。在A5区，几乎所有HSV1标记神经元也都含有酪氨酸羟化酶。在中缝核和锥体旁区，47%的HSV1阳性神经元含有血清素。标记神经元的分布与将HSV1注入肾上腺后观察到的分布相似。
