一种可阻断猫免疫缺陷病毒感染的单克隆抗体识别出一种可能的非CD4受体。
A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor.
作者信息
Hosie M J, Willett B J, Dunsford T H, Jarrett O, Neil J C
机构信息
Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden, Scotland.
出版信息
J Virol. 1993 Mar;67(3):1667-71. doi: 10.1128/JVI.67.3.1667-1671.1993.
Abstract
Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antibody may recognize an FIV receptor distinct from CD4.
摘要
单克隆抗体vpg15可检测到猫免疫缺陷病毒（FIV）易感猫细胞上一种24 kDa的细胞表面蛋白。该抗体可阻断FIV易感细胞的感染，并且在体外FIV感染的细胞中vpg15标记物的表达降低。这些结果表明，该抗体可能识别一种不同于CD4的FIV受体。
Zotero 插件