Leopardi R, Ilonen J, Mattila L, Salmi A A
Department of Virology, University of Turku, Finland.
Cell Immunol. 1993 Apr 1;147(2):388-96. doi: 10.1006/cimm.1993.1078.
We studied the effect of measles virus (MV) infection on the expression of MHC class II molecules and on the antigen-presenting function in human peripheral blood monocytes in vitro. The expression of HLA-DR, -DQ, and -DP molecules was up to 10-fold higher in MV-infected than that in uninfected monocytes. This effect did not change upon stimulation of monocytes with LPS, and was not mediated by IFN-gamma. In contrast to results obtained with peripheral monocytes, MV infection in a human monocytic cell line, THP-1, did not enhance the basic MHC class II expression, but strongly inhibited the IFN-gamma-induced expression. High levels of MHC class II expression in MV-infected monocytes were associated with capacity to present MV antigens, but the capacity to present unrelated antigens was strongly reduced. These results indicate how MV infection in monocytes may suppress the antigen-mediated T cell proliferation, still allowing the expansion of MV-specific T cell clones.
我们在体外研究了麻疹病毒（MV）感染对人外周血单核细胞中MHC II类分子表达及抗原呈递功能的影响。与未感染的单核细胞相比，MV感染的单核细胞中HLA-DR、-DQ和-DP分子的表达高达10倍。用脂多糖刺激单核细胞后，这种效应没有改变，且不受γ干扰素介导。与外周单核细胞的结果相反，MV感染人单核细胞系THP-1并未增强基础MHC II类表达，反而强烈抑制γ干扰素诱导的表达。MV感染的单核细胞中高水平的MHC II类表达与呈递MV抗原的能力相关，但呈递无关抗原的能力则大幅降低。这些结果表明单核细胞中的MV感染可能如何抑制抗原介导的T细胞增殖，同时仍允许MV特异性T细胞克隆的扩增。
