Arendt G, Hefter H, Jablonowski H
Dept of Neurology, University of Duesseldorf, FRG.
Electroencephalogr Clin Neurophysiol. 1993 Mar;86(3):152-60. doi: 10.1016/0013-4694(93)90002-d.
Cognitive event-related potentials (ERPs) were recorded in 33 HIV-positive individuals with clinical signs of dementia (group C) using an auditory oddball paradigm, in comparison to a healthy control group of comparable education and social environment (group A) and to a cohort of clinically asymptomatic HIV-positive individuals (group B). Parameters evaluated were: N1, P2, N2 and P3 latencies and N1-P2, P2-N2 and N2-P3 amplitudes. Results of group B and C were correlated with clinical findings, test psychometric performance and standard EEG records of both groups. The demented patients revealed significant prolongations of N2 and P3 peak latencies or complete abolition of these "endogenous," not stimulus-related, ERP peaks. Clinical bradykinetic symptoms and time-dependent psychometric abilities correlated with N2 and P3 latency prolongations and with the general slowing of the alpha rhythm, indicating an involvement of cortical and subcortical structures in HIV-related brain disease.
使用听觉oddball范式，对33名有痴呆临床症状的HIV阳性个体（C组）进行认知事件相关电位（ERP）记录，并与教育程度和社会环境相当的健康对照组（A组）以及一组临床无症状的HIV阳性个体（B组）进行比较。评估的参数包括：N1、P2、N2和P3潜伏期以及N1 - P2、P2 - N2和N2 - P3波幅。B组和C组的结果与临床发现、测试心理测量表现以及两组的标准脑电图记录相关。痴呆患者的N2和P3峰潜伏期显著延长，或者这些“内源性”而非与刺激相关的ERP峰完全消失。临床运动迟缓症状和随时间变化的心理测量能力与N2和P3潜伏期延长以及α节律的普遍减慢相关，表明皮质和皮质下结构参与了HIV相关脑病。
