Wong T Z, Jonsson E, Hoopes P J, Trembly B S, Heaney J A, Douple E B, Coughlin C T
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire.
Prostate. 1993;22(2):125-38. doi: 10.1002/pros.2990220205.
Benign prostatic hyperplasia (BPH) is a common disease of elderly men. The current definitive treatment for urinary obstruction caused by this disease is surgery (transurethral resection of the prostate, or TURP). Recent evidence suggests that hyperthermia may be a useful nonsurgical alternative for treatment of symptomatic BPH. A transurethral microwave applicator has been designed around a Foley catheter for delivery of local hyperthermia to the prostate. The Foley balloon is used to maintain the antenna position within the prostatic urethra. The Foley catheter also features an antenna choke to confine power deposition to the intended region. The antenna is a coaxial dipole designed to operate at 915 MHz. Qualitative and quantitative specific absorption rate (SAR) patterns are shown for this antenna. In vivo experiments in dog prostate demonstrate that temperatures > 42 degrees C can be obtained > 1 cm away from the catheter, while maintaining a maximum urethral temperature of 47 degrees C to 48 degrees C. Histology obtained acutely after the hyperthermia treatments showed minimal damage to the periurethral tissues. We conclude from these studies that this microwave applicator is capable of providing local hyperthermia to the prostatic tissues with a predictable and well-circumscribed thermal distribution.
良性前列腺增生（BPH）是老年男性的常见疾病。目前针对该疾病所致尿路梗阻的确定性治疗方法是手术（经尿道前列腺切除术，即TURP）。最近的证据表明，热疗可能是治疗有症状BPH的一种有用的非手术替代方法。一种经尿道微波施热器围绕一根Foley导管设计，用于向前列腺输送局部热疗。Foley球囊用于将天线位置维持在前列腺尿道内。Foley导管还具有一个天线扼流圈，以将功率沉积限制在预定区域。天线是一个设计为在915 MHz运行的同轴偶极子。展示了该天线的定性和定量比吸收率（SAR）模式。在犬前列腺的体内实验表明，在距导管1厘米以外的地方可达到>42摄氏度的温度，同时将尿道最高温度维持在47摄氏度至48摄氏度。热疗治疗后立即获取的组织学检查显示尿道周围组织损伤极小。我们从这些研究中得出结论，这种微波施热器能够以可预测且边界清晰的热分布向前列腺组织提供局部热疗。
