Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Okano T, Honke N, Tada S, Takahashi K, Kimura I
Division of Medicine, Misasa Medical Branch, Okayama University Medical School.
Arerugi. 1993 Jan;42(1):26-33.
A relationship of cellular composition in the airways and the release of chemical mediators from the cells to bronchial hyperresponsiveness was examined in two age-matched asthma groups: 15 atopic and 15 nonatopic patients. 1. A significant correlation between the proportion of eosinophils in bronchoalveolar lavage (BAL) fluid and bronchial reactivity (BR) was found in patients with atopic and nonatopic asthma. The proportion of the cells (combined eosinophils and neutrophils) in BAL fluid was closely correlated with BR in patients with atopic asthma, but not in those with nonatopic asthma. There was no correlation between the proportion of BAL neutrophils and BR in the two asthma groups. 2. There was a significant correlation between histamine release from BAL cells and BR in patients with atopic asthma. In contrast, LTC4 release from BAL cells was significantly corrected with BR in patients with nonatopic asthma. The results suggest that the humoral and cellular components in the airways, that participate in bronchial hyperresponsiveness, are different between patients with atopic and nonatopic asthma.
在两个年龄匹配的哮喘组中，研究了气道中的细胞组成以及细胞释放化学介质与支气管高反应性之间的关系：15名特应性患者和15名非特应性患者。1. 在特应性和非特应性哮喘患者中，发现支气管肺泡灌洗（BAL）液中嗜酸性粒细胞比例与支气管反应性（BR）之间存在显著相关性。BAL液中细胞（嗜酸性粒细胞和中性粒细胞总和）的比例与特应性哮喘患者的BR密切相关，但与非特应性哮喘患者无关。在两组哮喘患者中，BAL中性粒细胞比例与BR之间均无相关性。2. 特应性哮喘患者BAL细胞释放组胺与BR之间存在显著相关性。相比之下，非特应性哮喘患者BAL细胞释放LTC4与BR显著相关。结果表明，参与支气管高反应性的气道中的体液和细胞成分在特应性和非特应性哮喘患者之间存在差异。
