Mathangi D C, Namasivayam A
Department of Physiology, Sri Ramachandra Medical College and Research Institute, (DU), Madras 600 116, India.
Food Chem Toxicol. 2001 Oct;39(10):1039-43. doi: 10.1016/s0278-6915(01)00051-5.
In this study we evaluated the motor co-ordination in Wistar strain albino rats that were maintained on a protein-restricted diet for a period of 1 year immediately after the weaning period, by substituting 75% of the normal diet with a carbohydrate-rich diet deficient in protein, for a period of 1 year immediately after the weaning period. This type of chronic protein restriction caused disturbances in motor co-ordination. It also caused a significant reduction in the basal levels of dopamine, norepinephrine, epinephrine and serotonin along with their metabolites homovanillic acid (HVA), vanillyl mandelic acid (VMA) and 5-hydroxy indoleacetic acid (5HIAA) and precursor L-dopa in the corpus striatum and cerebellum. Changes in these neurotransmitters could have caused altered co-ordination in the protein-restricted animals.
在本研究中，我们评估了Wistar品系白化大鼠的运动协调性。这些大鼠在断奶期后立即采用蛋白质限制饮食饲养1年，即用富含碳水化合物但缺乏蛋白质的饮食替代正常饮食的75%。这种慢性蛋白质限制导致了运动协调性障碍。它还导致纹状体和小脑中多巴胺、去甲肾上腺素、肾上腺素和5-羟色胺的基础水平及其代谢产物高香草酸（HVA）、香草扁桃酸（VMA）和5-羟吲哚乙酸（5HIAA）以及前体左旋多巴显著降低。这些神经递质的变化可能导致了蛋白质限制动物的协调性改变。
