Minagawa Y, Kigawa J, Kanamori Y, Itamochi H, Terakawa N
Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.
Obstet Gynecol. 1993 Apr;81(4):610-4.
To determine whether cell kinetics in cervical cancer differ by patient age.
We analyzed specimens from 118 women who had been treated for cervical squamous cell carcinoma. In a preliminary study, labeling indices were determined in 16 patients using bromodeoxyuridine in vitro. Adjacent portions of the same specimens were analyzed by flow cytometry. Proliferation indices were calculated and compared with labeling indices for 12 diploid tumors. For the remaining 102 tumors, paraffin-embedded specimens were analyzed by flow cytometry to determine DNA ploidy and proliferation index. Using these findings, we examined the relationship between tumor cell kinetics and age.
There was a significant correlation between the labeling index and age (r = 0.86, P < .001) and a weak but statistically significant correlation between the proliferation index and the labeling index (r = 0.58, P < .05). The proportion of aneuploid tumors increased with age. The cutoff point of highest statistical significance was 65 years (P = .025). The proliferation index showed an age-dependent shift, and the cutoff point of highest statistical significance was also 65 years. Aneuploid tumors were more common in elderly patients aged 65 or more years. Proliferation indices were also significantly larger in the elderly patients (P < .005). Although stage III tumors were more common in the elderly, stage was not related to ploidy pattern or to proliferation index.
Tumor cell kinetics of cervical squamous cell carcinomas differ between elderly and younger women.
确定宫颈癌的细胞动力学是否因患者年龄而异。
我们分析了118例接受过宫颈鳞状细胞癌治疗的女性的标本。在一项初步研究中，使用溴脱氧尿苷在体外测定了16例患者的标记指数。对同一标本的相邻部分进行流式细胞术分析。计算增殖指数，并与12例二倍体肿瘤的标记指数进行比较。对于其余102例肿瘤，通过流式细胞术分析石蜡包埋标本，以确定DNA倍体和增殖指数。利用这些结果，我们研究了肿瘤细胞动力学与年龄之间的关系。
标记指数与年龄之间存在显著相关性（r = 0.86，P <.001），增殖指数与标记指数之间存在弱但统计学上显著的相关性（r = 0.58，P <.05）。非整倍体肿瘤的比例随年龄增加而增加。统计学意义最高的分界点为65岁（P =.025）。增殖指数显示出年龄依赖性变化，统计学意义最高的分界点也是65岁。非整倍体肿瘤在65岁及以上的老年患者中更为常见。老年患者的增殖指数也显著更高（P <.005）。尽管III期肿瘤在老年患者中更为常见，但分期与倍体模式或增殖指数无关。
老年女性和年轻女性的宫颈鳞状细胞癌肿瘤细胞动力学不同。
