Schomer D L
Department of Neurology, Beth Israel Hospital, Harvard University, Boston, MA 02215.
Epilepsia. 1993;34 Suppl 1:S29-36. doi: 10.1111/j.1528-1157.1993.tb05904.x.
Focal status epilepticus and epilepsia partialis continua (FSE-EPC) are most frequently seen with chronic focal progressive encephalitis of Rasmussen and Russian spring-summer encephalitis. FSE-EPC may be the presenting feature of nonketotic hyperglycemic diabetes mellitus but is more often noted as a late complication especially if there is a coexistent cerebral lesion such as cerebral infarction. FSE-EPC may be related to multiple sclerosis, primary or metastatic brain tumors, the MERRF-MELAS syndrome, benign epilepsy of childhood with rolandic spikes, and in some adults with acquired aphasia. The physiological origin of the myoclonic jerks seen in EPC is cortical and may be either spontaneous or provoked by the joint position of the affected limb. The treatment of FSE-EPC is influenced by the underlying disorder.
局灶性癫痫持续状态和持续性部分性癫痫（FSE-EPC）最常见于拉斯穆森慢性局灶性进行性脑炎和俄罗斯春夏脑炎。FSE-EPC可能是非酮症高血糖糖尿病的首发特征，但更常被视为晚期并发症，尤其是在存在脑梗死等并存脑病变的情况下。FSE-EPC可能与多发性硬化症、原发性或转移性脑肿瘤、肌阵挛性癫痫伴破碎红纤维-线粒体脑肌病综合征（MERRF-MELAS综合征）、伴有中央颞区棘波的儿童良性癫痫以及一些获得性失语的成年人有关。EPC中出现的肌阵挛性抽搐的生理起源是皮质性的，可能是自发的，也可能由患肢的关节位置诱发。FSE-EPC的治疗受潜在疾病的影响。
