Schober A, Malz C R, Meyer D L
Department of Neuroanatomy, School of Medicine, University of Göttingen, FRG.
Neurosci Lett. 1993 Mar 5;151(1):67-70. doi: 10.1016/0304-3940(93)90047-o.
Nitric oxide, a free radical, has recently been shown to exert major influences on CNS functions in mammals. It is synthesized by NO-synthase. For the first time, this study reveals this enzyme's existence in the CNS of a teleost fish and describes its distribution in the diencephalon, where the paraventricular organ displays an extraordinarily high activity. The study contributes to an evolutionary perspective of the biological role played by nitric oxide in the vertebrate CNS, and raises questions regarding the significance of this gas in cerebrospinal fluid-contacting neurons.
一氧化氮作为一种自由基，最近被证明对哺乳动物的中枢神经系统功能有重大影响。它由一氧化氮合酶合成。本研究首次揭示了这种酶在硬骨鱼中枢神经系统中的存在，并描述了其在间脑中的分布，其中室旁器官表现出极高的活性。该研究有助于从进化角度理解一氧化氮在脊椎动物中枢神经系统中所起的生物学作用，并引发了关于这种气体在脑脊液接触神经元中的意义的问题。
