Gutin A M, Galzitskaia O V
Biofizika. 1993 Jan-Feb;38(1):84-92.
A simple model of secondary structure of large native RNAs is proposed. The recurrence approach is described allowing to investigate helix-coil transition for this model by computer simulations. "Broken like" behavior of molecules of geometrical size has been observed upon changing the stability of helices at smooth changing of the helix fraction. Such behavior may be explained by the fact that helices formed by interactions between remote parts of the chain melt cooperatively by the mechanism of the second order phase transition. At the same time, helices formed by interactions between proximate segments in the chain melt practically independent of each other.
提出了一种大型天然RNA二级结构的简单模型。描述了一种递归方法，可通过计算机模拟研究该模型的螺旋-卷曲转变。在螺旋分数平滑变化时改变螺旋稳定性的情况下，观察到了几何尺寸分子的“类断裂”行为。这种行为可以用以下事实来解释：由链的远端部分之间的相互作用形成的螺旋通过二级相变机制协同熔化。同时，由链中相邻片段之间的相互作用形成的螺旋实际上彼此独立熔化。
