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J Virol. 1993 May;67(5):2903-7. doi: 10.1128/JVI.67.5.2903-2907.1993.
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J Virol. 2001 Mar;75(5):2468-71. doi: 10.1128/JVI.75.5.2468-2471.2001.
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Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes.腺病毒E3转基因在β细胞中的表达可预防自身免疫性糖尿病。
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Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus.γ干扰素对于β细胞的破坏以及胰岛素依赖型糖尿病的发展至关重要。
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7
Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.白细胞介素-2的局灶性表达不会打破对β细胞中表达的“自身”（病毒）抗原的无反应性，但会在抗自身免疫反应启动后增强自身免疫性疾病（糖尿病）的发展。
J Clin Invest. 1995 Feb;95(2):477-85. doi: 10.1172/JCI117688.
8
Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes.受H-2Db主要组织相容性复合体I类分子限制并呈递给细胞毒性T淋巴细胞的最佳淋巴细胞性脉络丛脑膜炎病毒序列。
J Virol. 1995 Apr;69(4):2297-305. doi: 10.1128/JVI.69.4.2297-2305.1995.
9
Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.在胸腺中表达病毒蛋白的转基因小鼠中细胞毒性T淋巴细胞反应的胸腺选择与适应性
J Exp Med. 1994 Nov 1;180(5):1901-10. doi: 10.1084/jem.180.5.1901.

本文引用的文献

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Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.针对小鼠MHC抗原的单克隆抗体。II. 针对H-2Ld抗原的抗体，小鼠主要组织相容性复合体第三个多态性位点的产物
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病毒与细胞毒性T淋巴细胞：病毒肽二级结构在主要组织相容性复合体I类相互作用中的关键作用

Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions.

作者信息

Gairin J E, Oldstone M B

机构信息

Laboratoire de Pharmacologie et Toxicologie Fondamentales, Centre National de la Recherche Scientifique, Toulouse, France.

出版信息

J Virol. 1993 May;67(5):2903-7. doi: 10.1128/JVI.67.5.2903-2907.1993.

DOI:10.1128/JVI.67.5.2903-2907.1993
PMID:7682632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC237616/
Abstract

Viral antigens are presented to cytotoxic T lymphocytes (CTLs) by H-2-restricted major histocompatibility complex (MHC) glycoproteins. Binding of the endogenously processed viral peptides (epitopes) to their specific MHC molecules is an early intracellular event in the recognition process and is necessary for subsequent killing of virus-infected cells by virus-specific CTLs. It is now well established that interaction between a viral antigenic peptide and MHC is dependent on the primary structure (length and amino acid sequence) of that antigen. Here we show, using the H-2Db-restricted epitope GP277-286 of lymphocytic choriomeningitis virus as a model, that the secondary structure (conformation) of the viral sequence also plays a crucial role in the binding of a viral antigen to MHC glycoprotein and in its subsequent presentation to virus-specific CTLs.

摘要

病毒抗原通过H-2限制性主要组织相容性复合体（MHC）糖蛋白呈递给细胞毒性T淋巴细胞（CTL）。内源性加工的病毒肽（表位）与其特异性MHC分子的结合是识别过程中的早期细胞内事件，对于随后病毒特异性CTL杀伤病毒感染细胞是必要的。现已充分证实，病毒抗原肽与MHC之间的相互作用取决于该抗原的一级结构（长度和氨基酸序列）。在此，我们以淋巴细胞性脉络丛脑膜炎病毒的H-2Db限制性表位GP277-286为模型，表明病毒序列的二级结构（构象）在病毒抗原与MHC糖蛋白的结合及其随后呈递给病毒特异性CTL的过程中也起着关键作用。