病毒与细胞毒性T淋巴细胞：病毒肽二级结构在主要组织相容性复合体I类相互作用中的关键作用
Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions.
作者信息
Gairin J E, Oldstone M B
机构信息
Laboratoire de Pharmacologie et Toxicologie Fondamentales, Centre National de la Recherche Scientifique, Toulouse, France.
出版信息
J Virol. 1993 May;67(5):2903-7. doi: 10.1128/JVI.67.5.2903-2907.1993.
Abstract
Viral antigens are presented to cytotoxic T lymphocytes (CTLs) by H-2-restricted major histocompatibility complex (MHC) glycoproteins. Binding of the endogenously processed viral peptides (epitopes) to their specific MHC molecules is an early intracellular event in the recognition process and is necessary for subsequent killing of virus-infected cells by virus-specific CTLs. It is now well established that interaction between a viral antigenic peptide and MHC is dependent on the primary structure (length and amino acid sequence) of that antigen. Here we show, using the H-2Db-restricted epitope GP277-286 of lymphocytic choriomeningitis virus as a model, that the secondary structure (conformation) of the viral sequence also plays a crucial role in the binding of a viral antigen to MHC glycoprotein and in its subsequent presentation to virus-specific CTLs.
摘要
病毒抗原通过H-2限制性主要组织相容性复合体（MHC）糖蛋白呈递给细胞毒性T淋巴细胞（CTL）。内源性加工的病毒肽（表位）与其特异性MHC分子的结合是识别过程中的早期细胞内事件，对于随后病毒特异性CTL杀伤病毒感染细胞是必要的。现已充分证实，病毒抗原肽与MHC之间的相互作用取决于该抗原的一级结构（长度和氨基酸序列）。在此，我们以淋巴细胞性脉络丛脑膜炎病毒的H-2Db限制性表位GP277-286为模型，表明病毒序列的二级结构（构象）在病毒抗原与MHC糖蛋白的结合及其随后呈递给病毒特异性CTL的过程中也起着关键作用。
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本文引用的文献
1
2
Prediction of protein conformation.蛋白质构象预测
Biochemistry. 1974 Jan 15;13(2):222-45. doi: 10.1021/bi00699a002.
3
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.在同基因或半同种异体系统中淋巴细胞性脉络丛脑膜炎体外T细胞介导的细胞毒性的限制。
Nature. 1974 Apr 19;248(5450):701-2. doi: 10.1038/248701a0.
4
5
Biologic significance and therapeutic implications of antigen/MHC interactions.抗原/MHC相互作用的生物学意义及治疗意义
Clin Immunol Immunopathol. 1989 Nov;53(2 Pt 2):S47-52. doi: 10.1016/0090-1229(89)90069-x.
6
Antigen recognition by class I-restricted T lymphocytes.I类限制性T淋巴细胞的抗原识别
Annu Rev Immunol. 1989;7:601-24. doi: 10.1146/annurev.iy.07.040189.003125.
7
Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.对一种九氨基酸糖蛋白表位进行精细剖析，该表位是淋巴细胞性脉络丛脑膜炎病毒特异性的、受I类分子限制的H-2Db细胞毒性T淋巴细胞所识别的主要决定簇。
J Exp Med. 1988 Aug 1;168(2):559-70. doi: 10.1084/jem.168.2.559.
8
Probing the role of proline as a recognition element in peptide antigens.探究脯氨酸作为肽抗原识别元件的作用。
Biochem Pharmacol. 1990 Jul 1;40(1):119-23. doi: 10.1016/0006-2952(90)90186-o.
9
Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers.
Cell. 1990 Jan 12;60(1):63-72. doi: 10.1016/0092-8674(90)90716-r.
10
Empty MHC class I molecules come out in the cold.空载的MHC I类分子在低温环境中暴露出来。
Nature. 1990 Aug 2;346(6283):476-80. doi: 10.1038/346476a0.
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