Falnoga I, Kregar I, Skreblin M, Tusek-Znidaric M, Stegnar P
Institute Jozef Stefan, University of Ljubljana, Slovenia.
Biol Trace Elem Res. 1993 Apr;37(1):71-83. doi: 10.1007/BF02789402.
In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were: 1. After long-term exposure, about 40% of mercury was found in the brain water-soluble phase (supernatant); 2. In brain supernatant, about 80% of Hg was found in the range of low-molecular-weight proteins; the MT-like protein Hg-Cu-Zn-thionein was isolated and partially characterized; 3. HgO vapor exposure resulted in increased tissue levels of essential Cu and Zn in addition to exogenous Hg; and 4. Experiments showed that HgO vapor exposure can induce the stimulation of rat brain MT synthesis.
为了研究汞（Hg）的代谢、其与金属硫蛋白（MT）的亲和力以及其对暴露于元素汞（HgO）蒸气的大鼠脑组织中必需金属铜和锌水平的影响，进行了调查。主要发现如下：1. 长期暴露后，约40%的汞存在于脑水溶性相（上清液）中；2. 在脑上清液中，约80%的汞存在于低分子量蛋白质范围内；分离并部分表征了类似MT的蛋白质Hg-Cu-Zn-硫蛋白；3. 除了外源性汞外，HgO蒸气暴露还导致必需铜和锌的组织水平升高；4. 实验表明，HgO蒸气暴露可诱导大鼠脑MT合成的刺激。
