Niiyama Y, Shimizu T, Abe M, Hishikawa Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Electroencephalogr Clin Neurophysiol. 1993 Apr;86(4):247-51. doi: 10.1016/0013-4694(93)90105-5.
Slow vertex response (SVR) to sound stimuli was used as an index to assess whether cortical reactivity in REM sleep with tonic mentalis EMG activity (stage 1-REM) corresponds to that in REM sleep or rather to that in stage 1 of NREM sleep. In 11 young adult subjects 3 night polygraphic records were made after administration of 25 or 50 mg of clomipramine or non-active placebo. Stage 1-REM was observed in the drug night in 8 of the 11 subjects. N1-P2 and P2-N2 amplitudes of SVR were markedly smaller in stage 1-REM than in stage 1, but were virtually of the same height in stage 1-REM and in stage REM. This indicates that cortical reactivity in stage 1-REM closely resembles the counterpart in stage REM. This finding corresponds well with the frequent emergence of vivid dreams in stage 1-REM, indicating that stage 1-REM observed in the present subjects probably represents REM sleep without muscle atonia.
对声音刺激的慢顶点反应（SVR）被用作一项指标，以评估在伴有颏肌紧张性肌电图活动的快速眼动睡眠（第1期快速眼动睡眠）中的皮质反应性是与快速眼动睡眠中的皮质反应性相对应，还是更类似于非快速眼动睡眠第1期的皮质反应性。在11名年轻成年受试者中，在给予25毫克或50毫克氯米帕明或无活性安慰剂后进行了3晚的多导睡眠图记录。11名受试者中有8名在用药当晚观察到了第1期快速眼动睡眠。SVR的N1-P2和P2-N2波幅在第1期快速眼动睡眠中明显小于第1期，但在第1期快速眼动睡眠和快速眼动睡眠期实际上高度相同。这表明第1期快速眼动睡眠中的皮质反应性与快速眼动睡眠期的皮质反应性非常相似。这一发现与第1期快速眼动睡眠中频繁出现生动梦境的情况非常吻合，表明在本研究受试者中观察到的第1期快速眼动睡眠可能代表没有肌肉张力缺失的快速眼动睡眠。
