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帕金森病睡眠障碍的治疗:从研究到临床实践

The Treatment of Sleep Disorders in Parkinson's Disease: From Research to Clinical Practice.

作者信息

Loddo Giuseppe, Calandra-Buonaura Giovanna, Sambati Luisa, Giannini Giulia, Cecere Annagrazia, Cortelli Pietro, Provini Federica

机构信息

Department of Biomedical and Neuromotor Sciences, University of Bologna , Bologna , Italy.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; Bellaria Hospital, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.

出版信息

Front Neurol. 2017 Feb 16;8:42. doi: 10.3389/fneur.2017.00042. eCollection 2017.

Abstract

Sleep disorders (SDs) are one of the most frequent non-motor symptoms of Parkinson's disease (PD), usually increasing in frequency over the course of the disease and disability progression. SDs include nocturnal and diurnal manifestations such as insomnia, REM sleep behavior disorder, and excessive daytime sleepiness. The causes of SDs in PD are numerous, including the neurodegeneration process itself, which can disrupt the networks regulating the sleep-wake cycle and deplete a large number of cerebral amines possibly playing a role in the initiation and maintenance of sleep. Despite the significant prevalence of SDs in PD patients, few clinical trials on SDs treatment have been conducted. Our aim is to critically review the principal therapeutic options for the most common SDs in PD. The appropriate diagnosis and treatment of SDs in PD can lead to the consolidation of nocturnal sleep, the enhancement of daytime alertness, and the amelioration of the quality of life of the patients.

摘要

睡眠障碍(SDs)是帕金森病(PD)最常见的非运动症状之一,通常会随着疾病进展和残疾程度加重而愈发频繁。睡眠障碍包括夜间和日间表现,如失眠、快速眼动睡眠行为障碍和日间过度嗜睡。帕金森病中睡眠障碍的病因众多,包括神经退行性变过程本身,这可能会扰乱调节睡眠-觉醒周期的神经网络,并消耗大量可能在睡眠起始和维持中起作用的脑胺。尽管帕金森病患者中睡眠障碍的患病率很高,但针对睡眠障碍治疗的临床试验却很少。我们的目的是严格审查帕金森病中最常见睡眠障碍的主要治疗选择。对帕金森病中睡眠障碍进行恰当的诊断和治疗可巩固夜间睡眠、提高日间警觉性并改善患者生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1186/5311042/5d0659fa9579/fneur-08-00042-g001.jpg

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