Antal A, Bodis-Wollner I, Ghilardi M F, Glover A, Mylin L, Toldi J
Department of Neurology, Mount Sinai School of Medicine, City University of New York, NY.
Electroencephalogr Clin Neurophysiol. 1993 Apr;86(4):268-74. doi: 10.1016/0013-4694(93)90108-8.
We studied acute and chronic effects of levo-acetyl-carnitine (LAC) on event-related potentials (ERPs) in 3 monkeys trained in a "go"/"no-go" visual "oddball" discrimination task. The stimuli were 2.5 cpd sinusoidal gratings differing in their respective orientation only (0 degrees or 45 degrees). Each monkey was trained to release a lever during a prespecified time window. Target stimulus presentation probabilities were between 0.25 and 0.5. ERPs had comparable mean latencies and amplitudes in all monkeys. Primary evoked potentials recorded to either the target or non-target stimulus did not change significantly as a result of LAC treatment. On the other hand, P300 latency decreased following LAC administration, with a maximum occurring in 15-20 min. The major effects of LAC were consistent within each animal and for all three of them.
我们研究了左旋乙酰肉碱（LAC）对3只经过“是/否”视觉“oddball”辨别任务训练的猴子事件相关电位（ERP）的急性和慢性影响。刺激物是空间频率为2.5周/度的正弦光栅，仅各自的方向不同（0度或45度）。每只猴子都经过训练，在预先设定的时间窗口内释放杠杆。目标刺激呈现概率在0.25至0.5之间。所有猴子的ERP具有可比的平均潜伏期和波幅。LAC治疗后，记录到的目标或非目标刺激的主要诱发电位没有显著变化。另一方面，LAC给药后P300潜伏期缩短，在15 - 20分钟时达到最大。LAC的主要作用在每只动物体内以及所有三只动物中都是一致的。
