Aida T, Abe H, Fujieda K, Matsuura N
Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo.
Neurol Med Chir (Tokyo). 1993 Mar;33(3):152-7. doi: 10.2176/nmc.33.152.
Clinical manifestations and endocrine functions were evaluated in 17 children with suprasellar germinoma. Polyuria and growth retardation were the most common initial symptoms. Physical and neurological examinations revealed diabetes insipidus in 17, growth retardation in five, and visual disturbance in three of the patients. Assessment of hypothalamic-pituitary function before treatment revealed pituitary deficits in all patients involving growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and adrenocorticotropic hormone. These pituitary dysfunctions persisted after tumor remission due to radiation therapy. These results indicate that children with suprasellar germinoma need long-term hormone replacement therapy to prevent growth retardation, thyroid dysfunction, and delayed secondary sexual development.
对17例鞍上生殖细胞瘤患儿的临床表现和内分泌功能进行了评估。多尿和生长发育迟缓是最常见的初始症状。体格检查和神经检查发现，17例患者有尿崩症，5例有生长发育迟缓，3例有视力障碍。治疗前对下丘脑-垂体功能的评估显示，所有患者均存在垂体功能缺陷，涉及生长激素、促甲状腺激素、黄体生成素、卵泡刺激素和促肾上腺皮质激素。由于放疗导致肿瘤缓解后，这些垂体功能障碍仍然存在。这些结果表明，鞍上生殖细胞瘤患儿需要长期激素替代治疗，以预防生长发育迟缓、甲状腺功能障碍和继发性性发育延迟。
