开蓬和营养不良对大鼠免疫反应的影响。

Effects of chlordecone and malnutrition on immune response in rats.

作者信息

Chetty K N, Brown K, Walker J, Woods L

机构信息

Department of Biological Sciences, Grambling State University, Louisiana 71245.

出版信息

Life Sci. 1993;52(18):PL175-80. doi: 10.1016/0024-3205(93)90114-i.

DOI:10.1016/0024-3205(93)90114-i

PMID:7683362

Abstract

Effect of Chlordecone (Cd) and malnutrition on total body and spleen weights, and plaque forming cells (PFC) were studied. Rats were fed on normal, calcium (Ca-D), protein (P-D) or Ca+P-deficient diets containing 0, 10 or 100 ppm of Cd for 2 or 4 weeks. High (95-100%) mortality was observed in malnourished rats treated with 100 ppm of Cd for 4 weeks. A slight decrease in body weight and an increase in spleen weight was observed in normal but not malnourished rats treated with 10 ppm of Cd for 4 weeks. PFC were significantly increased in both malnourished and Cd-treated rats. Similar increase in PFC was observed in rats fed on Ca-D but not P-D diet containing 10 or 100 ppm of Cd. Whereas, rats fed on Ca+P-D diet containing 100 ppm of Cd exhibited a significant decrease in PFC.

摘要

研究了十氯酮（Cd）和营养不良对大鼠体重、脾脏重量及空斑形成细胞（PFC）的影响。将大鼠分别喂食正常饮食、缺钙（Ca-D）、缺蛋白（P-D）或同时缺钙和蛋白（Ca+P-D）的饮食，这些饮食中含有0、10或100 ppm的Cd，持续2或4周。用100 ppm的Cd处理4周的营养不良大鼠出现了高死亡率（95-100%）。用10 ppm的Cd处理4周的正常大鼠体重略有下降，脾脏重量增加，但营养不良大鼠未出现此现象。营养不良大鼠和经Cd处理的大鼠的PFC均显著增加。在喂食含10或100 ppm Cd的Ca-D饮食但非P-D饮食的大鼠中也观察到PFC有类似增加。然而，喂食含100 ppm Cd的Ca+P-D饮食的大鼠PFC显著减少。