Chetty K N, Fantroy L, Landau G, Ivie G W
Department of Biological Sciences, Grambling State University, Louisiana 71245, USA.
Ecotoxicol Environ Saf. 1996 Apr;33(3):268-70. doi: 10.1006/eesa.1996.0034.
Male Sprague-Dawley rats were treated with 0, 1, 10, 50, and 100 ppm of chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. The control rats fed with Ca-D diet exhibited a significant increase in white blood cell (WBC) counts compared to the rats fed with Ca-S diet. Dietary calcium (Ca), however, did not elicit any significant effect on total iron content and iron-binding capacity (transferrin) of control rats, whereas Cd at higher concentrations significantly increased WBC counts, total iron, and iron-binding capacity in serum of both Ca-S and Ca-D rats. The data suggest that dietary Ca did not alter Cd-increased WBC count, total iron, and iron-binding capacity in serum of rat.
将雄性斯普拉格-道利大鼠分别用0、1、10、50和100 ppm的开蓬（Cd）混入钙充足（Ca-S）或钙缺乏（Ca-D）的饮食中处理15天。与喂食Ca-S饮食的大鼠相比，喂食Ca-D饮食的对照大鼠白细胞（WBC）计数显著增加。然而，膳食钙（Ca）对对照大鼠的总铁含量和铁结合能力（转铁蛋白）没有产生任何显著影响，而较高浓度的Cd显著增加了Ca-S和Ca-D大鼠血清中的WBC计数、总铁和铁结合能力。数据表明，膳食Ca不会改变大鼠血清中Cd增加的WBC计数、总铁和铁结合能力。
