对苯二酚和硝酸益康唑对V79中国仓鼠细胞微核的诱导作用。
Induction of micronuclei in V79 Chinese hamster cells by hydroquinone and econazole nitrate.
作者信息
Ellard S, Parry E M
机构信息
Molecular Biology Research Group, School of Biological Sciences, University College of Swansea, Singleton Park, UK.
出版信息
Mutat Res. 1993 May;287(1):87-91. doi: 10.1016/0027-5107(93)90147-8.
Two suspect aneugens (hydroquinone and econazole nitrate) were examined for their ability to induce micronuclei in a number of V79 Chinese hamster cell lines which express rat cytochrome P-450 cDNAs. Hydroquinone elevated micronucleated cell frequencies in a dose-dependent manner in cell lines V79, XEM2 (expresses CYP1A1) and SD1 (expresses CYP2B1). Econazole nitrate was an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). The different cell lines showed similar responses to the test agents, indicating that hydroquinone is not a substrate for biotransformation by rat CYP1A1 or CYP2B1, nor is econazole nitrate biotransformed by rat CYP1A1 or CYP1A2.
对两种可疑的非整倍体诱变剂（对苯二酚和硝酸益康唑）进行了检测，以考察它们在一些表达大鼠细胞色素P - 450 cDNA的V79中国仓鼠细胞系中诱导微核的能力。对苯二酚在细胞系V79、XEM2（表达CYP1A1）和SD1（表达CYP2B1）中以剂量依赖方式提高了微核化细胞频率。硝酸益康唑在细胞系V79、XEM2和XEMd - MZ（表达CYP1A2）的狭窄剂量范围内是微核的有效诱导剂。不同的细胞系对测试剂表现出相似的反应，这表明对苯二酚不是大鼠CYP1A1或CYP2B1生物转化的底物，硝酸益康唑也不会被大鼠CYP1A1或CYP1A2生物转化。
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